<a href=http://priligy.bond>priligy and viagra combination</a> Extensive research has been conducted to understand and overcome platinum resistance, and mechanisms of resistance can be categorized into several broad biological processes, including 1 regulation of drug entry, exit, accumulation, sequestration, and detoxification, 2 enhanced repair and tolerance of platinum induced DNA damage, 3 alterations in cell survival pathways, 4 alterations in pleiotropic processes and pathways, and 5 changes in the tumor microenvironment