PDE5 inhibitors are considered to be the standard therapy for erectile dysfunction. They can be taken with or without food. However, some PDE5 inhibitors may require a patient to adjust the dosage. Ideally, the ideal patient for PDE5 inhibitor therapy is a patient with no severe complications, but who can take the medication on a regular basis. Patients should also be warned against co-administration of PDE5 inhibitors with nitrates. PDE5 inhibitors should be administered in steps, as they can lead to hypotension. They should also be avoided in patients with cardiovascular disease, diabetes, or comorbid comorbidities. PDE5 inhibitors are safe to use when co-administered with ranolazine, an anti-hypertensive medication. However, the FDA has issued warnings about PDE5I-related hearing loss.
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