The emergence of hydroxychloroquine-resistant strains of Plasmodium falciparum, the parasite responsible for most cases of severe malaria, has raised concerns about the continued effectiveness of the medication for malaria prophylaxis and treatment.
hydroxychloroquine 400 mg Resistance to hydroxychloroquine is primarily attributed to mutations in the parasite's chloroquine resistance transporter gene, which impairs the drug's ability to accumulate within the parasite's digestive vacuole. As a result, alternative antimalarial medications are recommended for regions where hydroxychloroquine resistance is prevalent.
