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Hormones and other neurotransmitters, but also drugs, act upon receptors. "Their active substances bind to the receptors and modify the three-dimensional receptor arrangement regulating the downstream signal pathways," says Hannes Schihada
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yeezy boost 350 ute for Pharmacology and Toxicology at the University of W眉rzburg (JMU).A special case are G protein-coupled receptors (GPCR). "About 30 percent of all authorized drugs worldwide act upon these receptors," explains Hannes Schihada, "but their potential is not yet fully utilized." So far, it was not possible to test the effect of millions of potential drugs on the GPCR arrangement within a very short time. "This has been a stumbling block to the discovery of novel pharmaceutical substances and the research of still unknown GPCRs," says Dr. Isabella Maiellaro, who is in charge of the project together with Professor Martin Lohse.The JMU team has now developed a method that allows the determination of both activity and potency of GPCR liga KARACHI:Chief Mi
nb 993 nister (CM) Murad Ali has directed the transport department to make efforts to float an international tender for the Karachi Circular Railway (KCR) project so that it can be started on December 25, the birthday of Quaid-i-Azam Mohammad Ali Jinnah.He issued these directives while presiding over a meeting on the KCR at CM House on Friday
stanley shop . The meeting was attended by Transport and Information Minister Nasir Shah, Planning and Development Chairperson Muhammad Waseem, Principal Secretary to the CM Sohail Rajput, Transport Secretary Saeed Awan, Energy Secretary Agha Wasif and others. Top officials of various Chinese firms also attended the meeting.Railways adds 55 new engines to fleetThe CM said that the KCR is the most important project in the city and has been included in the China-Pak Economic Corridor after a lo
adidas campus verte t of effort. "I want to perform the groundbreaking ceremony of the project in December," the CM said.Briefing the CM, the transport minister said that the project
