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AFFiRiS, based in Vienna, Austria, has announced the start of the pre-clinical development of its first Parkinson's vaccine PD01. The vaccine will be investigated for efficacy in Parkinson models. On successful conclusio nike high dunk n of this preclinical evaluation, initial clinical testing could start in 2010/11.The Parkinson's vaccine specifically targets the alpha-synuclein (alpha-syn) protein, which is considered to be a key contributory element in Parkinson's disease.Although all details of the nike jordan disease are not yet fully understood, there is clear scientific evidence that the concentration and enrichment of alpha-syn in the brain are contributing factors in the progression of Parkinson's disease. Therefore, reducing the alpha-syn burden in the brain should have a positive impact on the course of the nike dunks donna disease - a hypothesis that was recently confirmed by the results of U.S. researchers working on animal models.Frank Mattner, Chief Scientific Officer at AFFiRiS, adds: "The great potential offered KARACHI:The aggressive bowling duo of Zahid Mehmood and Kashif Bhatti fired SBP to an innings and 118 run-win over Candyland on the second day of their second-round fixture of the Patron鈥檚 Trophy (Grade II) Cricket Tournament at the SBP Ground in Karachi on Tuesday.Candyland resumed their first innings on 36-4 but were bowled out for a paltry 147 as Bhatti took 5-34 and Mehmood claimed 4-55 runs to make Candyland follow-on.Still trailing by a massive 252 runs, Candyland were even more hopeless the second time around as they were dismissed for 134 with nb 530 Me ugg boots damen hmood and Bhatti adding six and three wickets respectively to their first innings haul.Patron鈥檚 Trophy: Aslam鈥檚 double century takes SBP to 399In another match, off-spinner Intizar Ali鈥檚 six-wickets helped PIA defeat Pakistan Oilfield Limited by an innings and 21 runs.Els newbalance 550 ewhere, centuries by Baber Hussain Aga and Hamza Ghanchi helped Navy post a massive 472-run total 鈥?64 more than PTV鈥檚 first innings total. Aga scored 179 off 159 balls